Identifying sources of human interictal discharges with travelling wave and white matter propagation.

ABSTRACT: Interictal epileptiform discharges have been shown to propagate from focal epileptogenic sources as travelling waves or through more rapid white matter conduction. We hypothesize that both modes of propagation are necessary to explain interictal discharge timing delays. We propose a method that, for the first time, incorporates both propagation modes to identify unique potential sources of interictal activity. We retrospectively analysed 38 focal epilepsy patients who underwent intracranial EEG recordings and diffusion-weighted imaging for epilepsy surgery evaluation. Interictal discharges were detected and localized to the most likely source based on relative delays in time of arrival across electrodes, incorporating travelling waves and white matter propagation. We assessed the influence

SUBMITTER: Withers CP 

PROVIDER: S-EPMC11046055 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature