High-intensity interval training combining rowing and cycling improves but does not restore beta-cell function in type 2 diabetes.

ABSTRACT:

Aim

We investigated whether a high-intensity interval training (HIIT) protocol could restore beta-cell function in type 2 diabetes compared with sedentary obese and lean individuals.

Materials and methods

In patients with type 2 diabetes, and age-matched, glucose-tolerant obese and lean controls, we examined the effect of 8 weeks of supervised HIIT combining rowing and cycling on the acute (first-phase) and second-phase insulin responses, beta-cell function adjusted for insulin sensitivity (disposition index), and serum free fatty acid (FFA) levels using the Botnia clamp (1-h IVGTT followed by 3-h hyperinsulinemic-euglycemic clamp).

Results

At baseline, patients with type 2 diabetes had reduced insulin sensitivity (~40%), acute insulin secretion (~13-fold), and dispos

SUBMITTER: Houborg Petersen M 

PROVIDER: S-EPMC11046351 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature