Recent advances in the discovery and development of drugs targeting the kallikrein-kinin system.

ABSTRACT:

Background

The kallikrein-kinin system is a key regulatory cascade involved in blood pressure maintenance, hemostasis, inflammation and renal function. Currently, approved drugs remain limited to the rare disease hereditary angioedema. However, growing interest in this system is indicated by an increasing number of promising drug candidates for further indications.

Methods

To provide an overview of current drug development, a two-stage literature search was conducted between March and December 2023 to identify drug candidates with targets in the kallikrein-kinin system. First, drug candidates were identified using PubMed and Clinicaltrials.gov. Second, the latest publications/results for these compounds were searched in PubMed, Clinicaltrials.gov and Google Scholar. The find

SUBMITTER: Wisniewski P 

PROVIDER: S-EPMC11046790 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature