Association of genetically predicted 486 blood metabolites on the risk of Alzheimer's disease: a Mendelian randomization study.

ABSTRACT:

Background

Studies have reported that metabolic disturbance exhibits in patients with Alzheimer's disease (AD). Still, the presence of definitive evidence concerning the genetic effect of metabolites on AD risk remains insufficient. A systematic exploration of the genetic association between blood metabolites and AD would contribute to the identification of new targets for AD screening and prevention.

Methods

We conducted an exploratory two-sample Mendelian randomization (MR) study aiming to preliminarily identify the potential metabolites involved in AD development. A genome-wide association study (GWAS) involving 7,824 participants provided information on 486 human blood metabolites. Outcome information was obtained from a large-scale GWAS meta-analysis of AD, encompassing

SUBMITTER: Yang Q 

PROVIDER: S-EPMC11047179 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature