Risk of Autism after Prenatal Topiramate, Valproate, or Lamotrigine Exposure.

ABSTRACT:

Background

Maternal use of valproate during pregnancy has been associated with an increased risk of neurodevelopmental disorders in children. Although most studies of other antiseizure medications have not shown increased risks of these disorders, there are limited and conflicting data regarding the risk of autism spectrum disorder associated with maternal topiramate use.

Methods

We identified a population-based cohort of pregnant women and their children within two health care utilization databases in the United States, with data from 2000 through 2020. Exposure to specific antiseizure medications was defined on the basis of prescription fills from gestational week 19 until delivery. Children who had been exposed to topiramate during the second half of pregnancy were compar

SUBMITTER: Hernandez-Diaz S 

PROVIDER: S-EPMC11047762 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature