Dataset Information

In Silico Analysis of the Ga³⁺/Fe³⁺ Competition for Binding the Iron-Scavenging Siderophores of P. aeruginosa-Implementation of Three Gallium-Based Complexes in the "Trojan Horse" Antibacterial Strategy.

ABSTRACT: The emergence of multidrug-resistant (MDR) microorganisms combined with the ever-draining antibiotic pipeline poses a disturbing and immensely growing public health challenge that requires a multidisciplinary approach and the application of novel therapies aimed at unconventional targets and/or applying innovative drug formulations. Hence, bacterial iron acquisition systems and bacterial Fe^2+/3+-containing enzymes have been identified as a plausible target of great potential. The intriguing "Trojan horse" approach deprives microorganisms from the essential iron. Recently, gallium's potential in medicine as an iron mimicry species has attracted vast attention. Different Ga³⁺ formulations exhibit diverse effects upon entering the cell and thus supposedly have multiple t

SUBMITTER: Kircheva N

PROVIDER: S-EPMC11048449 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Dataset Information

In Silico Analysis of the Ga³⁺/Fe³⁺ Competition for Binding the Iron-Scavenging Siderophores of P. aeruginosa-Implementation of Three Gallium-Based Complexes in the "Trojan Horse" Antibacterial Strategy.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

In Silico Analysis of the Ga3+/Fe3+ Competition for Binding the Iron-Scavenging Siderophores of P. aeruginosa-Implementation of Three Gallium-Based Complexes in the "Trojan Horse" Antibacterial Strategy.

OmicsDI is part of the ELIXIR infrastructure

Tweets

In Silico Analysis of the Ga³⁺/Fe³⁺ Competition for Binding the Iron-Scavenging Siderophores of P. aeruginosa-Implementation of Three Gallium-Based Complexes in the "Trojan Horse" Antibacterial Strategy.