Molecular Epidemiology of Carbapenem-Resistant Klebsiella aerogenes in Japan.

ABSTRACT: Information regarding Klebsiella aerogenes haboring carbapenemase in Japan is limited. A comprehensive nationwide survey was conducted from September 2014 to December 2022, and 67 non-duplicate strains of carbapenem-resistant K. aerogenes were isolated from 57 healthcare facilities in Japan. Through genetic testing and whole-genome sequencing, six strains were found to possess carbapenemases, including imipenemase (IMP)-1, IMP-6, New Delhi metallo-β-lactamase (NDM)-1, and NDM-5. The strain harboring bla_NDM-5 was the novel strain ST709, which belongs to the clonal complex of the predominant ST4 in China. The novel integron containing bla_IMP-1 featured the oxacillinase-101 gene, which is a previously unreported structure, with an IncN_4</

SUBMITTER: Takei K 

PROVIDER: S-EPMC11049973 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature