Chemerin Stimulates the Secretory Activity of BME-UV1 Bovine Mammary Epithelial Cells.

ABSTRACT: Adipose tissue is an active endocrine gland, synthesizing and secreting multiple signaling molecules termed adipokines. Following the detection of adipokines and their receptors in the mammary tissue of various species, it is indicated that adipokines play a role in the development of the mammary gland. The aim of the present study was to determine the concentration-dependent influence of three adipokines, leptin, adiponectin, and chemerin, on the viability, apoptosis, and secretory activity of BME-UV1 bovine mammary epithelial cells. The study confirmed that BME-UV1 cells contain the leptin receptor (Ob-R) protein, and express transcripts of adiponectin (ADIPOR1 and ADIPOR2) and chemerin (CMLKR1 and GPR1) receptors. Regardless of the administered dose, none of

SUBMITTER: Dziegelewska-Sokolowska Z 

PROVIDER: S-EPMC11050135 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature