Association of Gene Polymorphisms with Normal Tension Glaucoma: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Normal tension glaucoma (NTG) is becoming a more and more serious problem, especially in Asia. But the pathological mechanisms are still not illustrated clearly. We carried out this research to uncover the gene polymorphisms with NTG.

Methods

We searched in Web of Science, Embase, Pubmed and Cochrane databases for qualified case-control studies investigating the association between single nucleotide polymorphisms (SNPs) and NTG risk. Odds ratios (ORs) and 95% confidence intervals (CIs) for each SNP were estimated by fixed- or random-effect models. Sensitivity analysis was also performed to strengthen the reliability of the results.

Results

Fifty-six studies involving 33 candidate SNPs in 14 genetic loci were verified to be eligible for our meta-analysis. Si

SUBMITTER: Pan L 

PROVIDER: S-EPMC11050218 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature