K⁺-Driven Cl^-/HCO₃^- Exchange Mediated by Slc4a8 and Slc4a10.

ABSTRACT: Slc4a genes encode various types of transporters, including Na⁺-HCO₃^- cotransporters, Cl^-/HCO₃^- exchangers, or Na⁺-driven Cl^-/HCO₃^- exchangers. Previous research has revealed that Slc4a9 (Ae4) functions as a Cl^-/HCO₃^- exchanger, which can be driven by either Na⁺ or K⁺, prompting investigation into whether other Slc4a members facilitate cation-dependent anion transport. In the present study, we show that either Na⁺ or K⁺ drive Cl^-/HCO₃^- exchanger activity in cells overexpressing Slc4a8 or Slc4a10. Further characterization of cation-driven Cl^-/HCO₃^-

SUBMITTER: Pena-Munzenmayer G 

PROVIDER: S-EPMC11050268 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature