Association between Genetic Polymorphism of <i>SCN1A</i>, <i>GABRA1</i> and <i>ABCB1</i> and Drug Responsiveness in Vietnamese Epileptic Children.

ABSTRACT: Background and Objectives: Drug resistant epilepsy (DRE) is a major hurdle in epilepsy, which hinders clinical care, patients' management and treatment outcomes. DRE may partially result from genetic variants that alter proteins responsible for drug targets and drug transporters in the brain. We aimed to examine the relationship between SCN1A, GABRA1 and ABCB1 polymorphism and drug response in epilepsy children in Vietnam. Materials and Methods: In total, 213 children diagnosed with epilepsy were recruited in this study (101 were drug responsive and 112 were drug resistant). Sanger sequencing had been performed in order to detect six single nucleotide polymorphisms (SNPs) belonging to SCN1A (rs2298771, rs3812718, rs10188577), GABRA1 (rs22790

SUBMITTER: Tang HX 

PROVIDER: S-EPMC11052159 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature