The Prediction of LptA and LptC Protein-Protein Interactions and Virtual Screening for Potential Inhibitors.

ABSTRACT: Antibiotic resistance in Gram-negative bacteria remains one of the most pressing challenges to global public health. Blocking the transportation of lipopolysaccharides (LPS), a crucial component of the outer membrane of Gram-negative bacteria, is considered a promising strategy for drug discovery. In the transportation process of LPS, two components of the LPS transport (Lpt) complex, LptA and LptC, are responsible for shuttling LPS across the periplasm to the outer membrane, highlighting their potential as targets for antibacterial drug development. In the current study, a protein-protein interaction (PPI) model of LptA and LptC was constructed, and a molecular screening strategy was employed to search a protein-protein interaction compound library. The screening results indicated that co

SUBMITTER: Ren Y 

PROVIDER: S-EPMC11052386 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature