Hypogonadism and neurocognitive outcomes among childhood cancer survivors.

ABSTRACT:

Objective

Childhood cancer survivors are at risk for hypogonadism. The impact of hypogonadism on neurocognitive impairment and emotional distress in the non-cancer population has been shown; however, the relationship among the childhood cancer survivor population is unknown. We aimed to evaluate the contribution of hypogonadism to neurocognitive impairment and emotional distress among survivors.

Design

Cross-sectional study using retrospective cohort.

Methods

In total, 3628 survivors who completed standard neurocognitive tests (six domains: processing speed, memory, executive function, attention, academics, and global cognition) and self-reported emotional distress were included in our study. Participants were stratified by sex and gonadal status. Outcomes were compar

SUBMITTER: Yoshida T 

PROVIDER: S-EPMC11052539 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature