Hydration water drives the self-assembly of guanosine monophosphate.

ABSTRACT: Guanosine monophosphate (GMP) is a nucleotide that can self-assemble in aqueous solution under certain conditions. An understanding of the process at the molecular level is an essential step to comprehend the involvement of DNA substructures in transcription and replication, as well as their relationship to genetic diseases such as cancer. We present the temperature-dependent terahertz (1.5-12 THz, 50-400 cm^-1) absorptivity spectra of aqueous Na₂ GMP solution in comparison with the aqueous solutions of other RNA nucleotides. Distinct absorption features were observed in the spectrum of GMP, which we attribute to the intramolecular modes of the self-assemblies (i.e., G-complexes) that, at 1 M, start to form at 313 K and below. Changes in broad-band features of the tera

SUBMITTER: Tao YH 

PROVIDER: S-EPMC11052693 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature