Glutamatergic neurons in ventral pallidum modulate heroin addiction via epithalamic innervation in rats.

ABSTRACT: Glutamatergic neurons in ventral pallidum (VP^Glu) were recently reported to mediate motivational and emotional behavior, but its role in opioid addiction still remains to be elucidated. In this study we investigated the function of VP^Glu in the context-dependent heroin taking and seeking behavior in male rats under the ABA renewal paradigm. By use of cell-type-specific fiber photometry, we showed that the calcium activity of VP^Glu were inhibited during heroin self-administration and context-induced relapse, but activated after extinction in a new context. The drug seeking behavior was accompanied by the decreased calcium signal of VP^Glu. Chemogenetic manipulation of VP^Glu bidirectionally regulated heroin taking and seeking behavior. An

SUBMITTER: Chen RS 

PROVIDER: S-EPMC11053033 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature