Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of developing human retina.

ABSTRACT: The emergence of retinal progenitor cells and differentiation to various retinal cell types represent fundamental processes during retinal development. Herein, we provide a comprehensive single cell characterisation of transcriptional and chromatin accessibility changes that underline retinal progenitor cell specification and differentiation over the course of human retinal development up to midgestation. Our lineage trajectory data demonstrate the presence of early retinal progenitors, which transit to late, and further to transient neurogenic progenitors, that give rise to all the retinal neurons. Combining single cell RNA-Seq with spatial transcriptomics of early eye samples, we demonstrate the transient presence of early retinal progenitors in the ciliary margin zone with decreasing oc

SUBMITTER: Dorgau B 

PROVIDER: S-EPMC11053058 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature