A cluster-randomized trial of water, sanitation, handwashing and nutritional interventions on stress and epigenetic programming.

ABSTRACT: A regulated stress response is essential for healthy child growth and development trajectories. We conducted a cluster-randomized trial in rural Bangladesh (funded by the Bill & Melinda Gates Foundation, ClinicalTrials.gov NCT01590095) to assess the effects of an integrated nutritional, water, sanitation, and handwashing intervention on child health. We previously reported on the primary outcomes of the trial, linear growth and caregiver-reported diarrhea. Here, we assessed additional prespecified outcomes: physiological stress response, oxidative stress, and DNA methylation (N = 759, ages 1-2 years). Eight neighboring pregnant women were grouped into a study cluster. Eight geographically adjacent clusters were block-randomized into the control or the combined nutrition, water, sanitation,

SUBMITTER: Lin A 

PROVIDER: S-EPMC11053067 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature