Accelerated epigenetic age is associated with whole-brain functional connectivity and impaired cognitive performance in older adults.

ABSTRACT: While chronological age is a strong predictor for health-related risk factors, it is an incomplete metric that fails to fully characterize the unique aging process of individuals with different genetic makeup, neurodevelopment, and environmental experiences. Recent advances in epigenomic array technologies have made it possible to generate DNA methylation-based biomarkers of biological aging, which may be useful in predicting a myriad of cognitive abilities and functional brain network organization across older individuals. It is currently unclear which cognitive domains are negatively correlated with epigenetic age above and beyond chronological age, and it is unknown if functional brain organization is an important mechanism for explaining these associations. In this study, individuals w

SUBMITTER: Graves AJ 

PROVIDER: S-EPMC11053089 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature