Profiling functional networks identify activation of corticostriatal connectivity in ET patients after MRgFUS thalamotomy.

ABSTRACT:

Background

MR-guided focused ultrasound (MRgFUS) thalamotomy is a novel and effective treatment for medication-refractory tremor in essential tremor (ET), but how the brain responds to this deliberate lesion is not clear.

Objective

The current study aimed to evaluate the immediate and longitudinal alterations of functional networks after MRgFUS thalamotomy.

Methods

We retrospectively obtained preoperative and postoperative 30-day, 90-day, and 180-day data of 31 ET patients subjected with MRgFUS thalamotomy from 2018 to 2020. Their archived resting-state functional MRI data were used for functional network comparison as well as graph-theory metrics analysis. Both partial least squares (PLS) regression and linear regression were conducted to associate functional feature

SUBMITTER: Lin J 

PROVIDER: S-EPMC11053244 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature