Gold(I) and Silver(I) Complexes Containing Hybrid Sulfonamide/Thiourea Ligands as Potential Leishmanicidal Agents.

ABSTRACT: Leishmaniasis is a group of parasitic diseases with the potential to infect more than 1 billion people; however, its treatment is still old and inadequate. In order to contribute to changing this view, this work consisted of the development of complexes derived from M^I metal ions with thioureas, aiming to obtain potential leishmanicidal agents. The thiourea ligands (HL^R) were obtained by reactions of p-toluenesulfohydrazide with R-isothiocyanates and were used in complexation reactions with Ag^I and Au^I, leading to the formation of complexes of composition [M(HL^R)₂]X (M = Ag or Au; X = NO₃^- or Cl^-). All compounds were characterized by FTIR, ¹H NMR, UV-vis, emission spectrosco

SUBMITTER: Borges AP 

PROVIDER: S-EPMC11053681 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature