Sandalwood Oils of Different Origins Are Active In Vitro against <i>Madurella mycetomatis</i>, the Major Fungal Pathogen Responsible for Eumycetoma.

ABSTRACT: In the search for new bioactive agents against the infectious pathogen responsible for the neglected tropical disease (NTD) mycetoma, we tested a collection of 27 essential oils (EOs) in vitro against Madurella mycetomatis, the primary pathogen responsible for the fungal form of mycetoma, termed eumycetoma. Among this series, the EO of Santalum album (Santalaceae), i.e., East Indian sandalwood oil, stood out prominently with the most potent inhibition in vitro. We, therefore, directed our research toward 15 EOs of Santalum species of different geographical origins, along with two samples of EOs from other plant species often commercialized as "sandalwood oils". Most of these EOs displayed similar strong activity against M. mycetomatis in vitro. All tested oils w

SUBMITTER: Abd Algaffar SO 

PROVIDER: S-EPMC11055130 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature