Poor statistical power in population-based association study of gene interaction.

ABSTRACT:

Background

Statistical epistasis, or "gene-gene interaction" in genetic association studies, means the nonadditive effects between the polymorphic sites on two different genes affecting the same phenotype. In the genetic association analysis of complex traits, nevertheless, the researchers haven't found enough clues of statistical epistasis so far.

Methods

We developed a statistical model where the statistical epistasis was presented as an extra linkage disequilibrium between the polymorphic sites of different risk genes. The power of statistical test for identifying the gene-gene interaction was calculated and then compared in different hypothesis scenarios.

Results

Our results show the statistical power increases with the increasing of interaction coefficient, relat

SUBMITTER: Ma J 

PROVIDER: S-EPMC11055307 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature