Serum calcitonin gene-related peptide in patients with persistent post-concussion symptoms, including headache: a cohort study.

ABSTRACT:

Background

Calcitonin gene-related peptide (CGRP) plays an important role in migraine pathophysiology, and post-traumatic headache (PTH) frequently presents with migraine-like features. Despite several clinical similarities, few studies have explored CGRP in PTH and concussion. This study investigates serum CGRP levels in patients with persistent post-concussion symptoms (PPCS), including PTH.

Methods

This cohort study was based on serum samples from individuals aged 18-30 years with PPCS who participated in a previously published randomized controlled trial of a non-pharmacological intervention. The primary outcome was serum CGRP concentrations, determined at baseline before randomization and at follow-up 7 months later, using an enzyme-linked immunosorbent assay (ELISA). C

SUBMITTER: Eggertsen PP 

PROVIDER: S-EPMC11055722 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature