Altered mucosal bacteria and metabolomics in patients with Peutz-Jeghers syndrome.

ABSTRACT:

Background

Peutz-Jeghers syndrome (PJS) is a rare genetic disorder characterized by the development of pigmented spots, gastrointestinal polyps and increased susceptibility to cancers. Currently, most studies have investigated intestinal microbiota through fecal microbiota, and there are few reports about mucosa-associated microbiota. It remains valuable to search for the key intestinal microbiota or abnormal metabolic pathways linked to PJS.

Aim

This study aimed to assess the structure and composition of mucosa-associated microbiota in patients with PJS and to explore the potential influence of intestinal microbiota disorders and metabolite changes on PJS.

Methods

The bacterial composition was analyzed in 13 PJS patients and 12 controls using 16S rRNA gene sequencing

SUBMITTER: Wang S 

PROVIDER: S-EPMC11056063 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature