Leukocyte Telomere Length and Cardiac Structure and Function: A Mendelian Randomization Study.

ABSTRACT:

Background

Existing research demonstrates the association of shorter leukocyte telomere length with increased risk of age-related health outcomes including cardiovascular diseases. However, the direct causality of these relationships has not been definitively established. Cardiovascular aging at an organ level may be captured using image-derived phenotypes of cardiac anatomy and function.

Methods and results

In the current study, we use 2-sample Mendelian randomization to assess the causal link between leukocyte telomere length and 54 cardiac magnetic resonance imaging measures representing structure and function across the 4 cardiac chambers. Genetically predicted shorter leukocyte telomere length was causally linked to smaller ventricular cavity sizes including left ventri

SUBMITTER: Salih AM 

PROVIDER: S-EPMC11056120 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature