Impaired fertility in adenomyosis: a murine model reveals endometrial receptivity and progesterone resistance imbalances.

ABSTRACT:

In brief

The impact of adenomyosis on reproductive health needs to be fully understood. By using a murine model, this study provides novel insights into the nuanced mechanisms associated with fertility challenges and offers a foundation for targeted interventions.

Abstract

This study investigates the intricate relationship between adenomyosis and reproductive health using a murine model, offering novel insights into this prevalent gynecological disorder. Adenomyosis, characterized by the invasive growth of endometrial tissue into the myometrium, is believed to negatively impact fertility. However, the challenge lies in disentangling this influence, as adenomyosis often coexists with other gynecological diseases. A tamoxifen-induced mice model presents a significant advantage

SUBMITTER: Squatrito M 

PROVIDER: S-EPMC11056956 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature