Large-scale genome-wide association studies reveal the genetic causal etiology between air pollutants and autoimmune diseases.

ABSTRACT:

Background

Epidemiological evidence links a close correlation between long-term exposure to air pollutants and autoimmune diseases, while the causality remained unknown.

Methods

Two-sample Mendelian randomization (TSMR) was used to investigate the role of PM10, PM2.5, NO₂, and NO_X (N = 423,796-456,380) in 15 autoimmune diseases (N = 14,890-314,995) using data from large European GWASs including UKB, FINNGEN, IMSGC, and IPSCSG. Multivariable Mendelian randomization (MVMR) was conducted to investigate the direct effect of each air pollutant and the mediating role of common factors, including body mass index (BMI), alcohol consumption, smoking status, and household income. Transcriptome-wide association studies (TWAS), two-step MR, and colocalization analy

SUBMITTER: Wen J 

PROVIDER: S-EPMC11057084 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature