Association of high disease activity and serum IL-6 levels with the incidence of inflammatory major organ events in Behcet disease: a prospective registry study.

ABSTRACT:

Background

Little is known about the relationship between the disease activity of Behçet disease (BD) and the incidence of inflammatory major organ events.

Objectives

In this prospective registry study, we investigated the association between the Behçet Disease Current Activity Form (BDCAF) and incidence of inflammatory major organ events, defined as the inflammation of the ocular, central nervous, intestinal, and vascular systems in BD.

Methods

We enrolled participants from Japanese multicenter prospective cohorts. The BDCAF was evaluated annually. BD-related symptoms, including inflammatory major organ events, were monitored. The association between BDCAF and inflammatory major organ events was analyzed by time-to-event analysis. An unsupervised clustering of the pa

SUBMITTER: Hirahara L 

PROVIDER: S-EPMC11057327 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature