Distance-based novelty detection model for identifying individuals at risk of developing Alzheimer's disease.

ABSTRACT:

Introduction

Novelty detection (ND, also known as one-class classification) is a machine learning technique used to identify patterns that are typical of the majority class and can discriminate deviations as novelties. In the context of Alzheimer's disease (AD), ND could be employed to detect abnormal or atypical behavior that may indicate early signs of cognitive decline or the presence of the disease. To date, few research studies have used ND to discriminate the risk of developing AD and mild cognitive impairment (MCI) from healthy controls (HC).

Methods

In this work, two distinct cohorts with highly heterogeneous data, derived from the Australian Imaging Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing project and the Fujian Medical University Union Hospital (FMU

SUBMITTER: Yang H 

PROVIDER: S-EPMC11057441 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature