Extracellular vesicles from <i>Fusobacterium nucleatum</i>: roles in the malignant phenotypes of gastric cancer.

ABSTRACT: The increase of the Fusobacterium nucleatum level has been previously identified in various cancers including gastric cancer (GC), but how the F. nucleatum exerts its carcinogenic role in GC remains unclear. Several studies revealed that F. nucleatum contributes to cancer progression via its secretion of extracellular vehicles (EVs). Hence, it's designed to reveal the influence of F. nucleatum-derived EVs (Fn-EVs) in GC progression. The tumor and adjacent tissues were collected from 30 GC patients, and the abundance of F. nucleatum was found to be highly expressed in tumor samples. The ultracentrifugation was employed to isolate EVs from F. nucleatum and Escherischia coli (E. coli), which were labeled Fn-EVs and E. coli-EVs, re

SUBMITTER: Meng X 

PROVIDER: S-EPMC11057558 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature