Effects of <i>Ninjurin 2</i> polymorphisms on susceptibility to coronary heart disease.

ABSTRACT:

Objective

The aim of this study was to explore the effects of Ninjurin 2 (NINJ2) polymorphisms on susceptibility to coronary heart disease (CHD).

Methods

We conducted a case-control study with 499 CHD cases and 505 age and gender-matched controls. Five single nucleotide polymorphisms (SNPs) in NINJ2 (rs118050317, rs75750647, rs7307242, rs10849390, and rs11610368) were genotyped by the Agena MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression analysis to assess the association of NINJ2 polymorphisms and CHD risk-adjusted for age and gender. What's more, risk genes and molecular functions were screened via protein-protein interaction (PPI) network and functional enrichment analysis.

Results

Rs118050317 in NI

SUBMITTER: Yan Y 

PROVIDER: S-EPMC11057668 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature