The longitudinal association of adipose-to-lean ratio with incident cardiometabolic morbidity: The CARDIA study.

ABSTRACT:

Aim

To assess the association of adipose-to-lean ratio (ALR) with incident type 2 diabetes mellitus (T2DM), hypertension, and dyslipidemia in middle adulthood.

Method

Black and White Coronary Artery Risk Development in Young Adults participants without T2DM, hypertension, or dyslipidemia in 2005-06 (baseline) were included. Baseline adipose and lean mass were assessed via dual-energy X-ray absorptiometry. ALR was calculated as adipose divided by lean mass and then standardized within sex strata. Single time-point incident morbidity was assessed every five years from baseline through 2016. Cox proportional hazards regression was used to estimate hazard ratios (HR) for morbidity over 10 years per 1-SD increment in ALR adjusted for cardiovascular risk factors.

Result

The

SUBMITTER: Booker R 

PROVIDER: S-EPMC11058009 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature