Trial Design for Mixed Urinary Incontinence: Midurethral Sling Versus Botulinum Toxin A.

ABSTRACT:

Importance

Mixed urinary incontinence (MUI) is common and can be challenging to manage.

Objectives

We present the protocol design and rationale of a trial comparing the efficacy of 2 procedures for the treatment of women with MUI refractory to oral treatment. The Midurethral sling versus Botulinum toxin A ( MUSA) trial compares the efficacy of intradetrusor injection of 100 U of onabotulinimtoxinA (an office-based procedure directed at the urgency component) versus midurethral sling (MUS) placement (a surgical procedure directed at the stress component).

Study design

The MUSA is a multicenter, randomized trial of women with MUI electing to undergo procedural treatment for MUI at 7 clinical centers in the NICHD Pelvic Floor Disorders Network. Participants are randomize

SUBMITTER: Harvie HS 

PROVIDER: S-EPMC11058039 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature