The S100 family is a prognostic biomarker and correlated with immune cell infiltration in pan-cancer.

ABSTRACT:

Background

The S100 protein family is a group of small molecular EF-hand calcium-binding proteins that play critical roles in various biological processes, including promotion of growth, metastasis and immune evasion of tumor. However, the potential roles of S100 protein family expression in tumor microenvironment (TME) cell infiltration in pan-cancer remain elusive.

Methods

Herein, we conducted a comprehensive assessment of the expression patterns of the S100 protein family in pan-cancer, meticulously examining their correlation with characteristics of TME cell infiltration. The S100 score was constructed to quantify S100 family expression patterns of individual tumors.

Results

The S100 family was a potent risk factor in many cancers. Clustering analysis based on the

SUBMITTER: Liang X 

PROVIDER: S-EPMC11058162 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature