Transcriptomic analysis reveals the crosstalk between type 2 diabetes and chronic pancreatitis.

ABSTRACT:

Background and aims

Mounting evidence highlights a strong association between chronic pancreatitis (CP) and type 2 diabetes (T2D), although the exact mechanism of interaction remains unclear. This study aimed to investigate the crosstalk genes and pathogenesis between CP and T2D.

Methods

Transcriptomic gene expression profiles of CP and T2D were extracted from Gene Expression Omnibus, respectively, and the common differentially expressed genes (DEGs) were subsequently identified. Further analysis, such as Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), protein-protein interaction, transcription factors (TFs), microRNA (miRNAs), and candidate chemicals identification, was performed to explore the possible common signatures between the two diseases.

Resu

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11058262 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature