The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults.

ABSTRACT:

Aims/hypothesis

Type 1 diabetes is an heterogenous condition. Characterising factors explaining differences in an individual's clinical course and treatment response will have important clinical and research implications. Our aim was to explore type 1 diabetes heterogeneity, as assessed by clinical characteristics, autoantibodies, beta cell function and glycaemic outcomes, during the first 12 months from diagnosis, and how it relates to age at diagnosis.

Methods

Data were collected from the large INNODIA cohort of individuals (aged 1.0-45.0 years) newly diagnosed with type 1 diabetes, followed 3 monthly, to assess clinical characteristics, C-peptide, HbA_1c and diabetes-associated antibodies, and their changes, during the first 12 months from diagnosis, across thre

SUBMITTER: Marcovecchio ML 

PROVIDER: S-EPMC11058619 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature