A comparative analysis of transcriptomics of newly diagnosed multiple myeloma: exploring drug repurposing.

ABSTRACT: Multiple myeloma (MM) is an incurable malignant plasma cell disorder characterized by the infiltration of clonal plasma cells in the bone marrow compartment. Gene Expression Profiling (GEP) has emerged as a powerful investigation tool in modern myeloma research enabling the dissection of the molecular background of MM and allowing the identification of gene products that could potentially serve as targets for therapeutic intervention. In this study we investigated shared transcriptomic abnormalities across newly diagnosed multiple myeloma (NDMM) patient cohorts. In total, publicly available transcriptomic data of 7 studies from CD138+ cells from 281 NDMM patients and 44 healthy individuals were integrated and analyzed. Overall, we identified 28 genes that were consistently differentially e

SUBMITTER: Giannakoulas A 

PROVIDER: S-EPMC11058662 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature