Metabolic effect of adrenaline infusion in people with type 1 diabetes and healthy individuals.

ABSTRACT:

Aims/hypothesis

As a result of early loss of the glucagon response, adrenaline is the primary counter-regulatory hormone in type 1 diabetes. Diminished adrenaline responses to hypoglycaemia due to counter-regulatory failure are common in type 1 diabetes, and are probably induced by exposure to recurrent hypoglycaemia, however, the metabolic effects of adrenaline have received less research attention, and also there is conflicting evidence regarding adrenaline sensitivity in type 1 diabetes. Thus, we aimed to investigate the metabolic response to adrenaline and explore whether it is modified by prior exposure to hypoglycaemia.

Methods

Eighteen participants with type 1 diabetes and nine healthy participants underwent a three-step ascending adrenaline infusion during a hyperins

SUBMITTER: She R 

PROVIDER: S-EPMC11058679 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature