Platelets induce CD39 expression in tumor cells to facilitate tumor metastasis.

ABSTRACT:

Background

Tumor cells continue to evolve the metastatic potential in response to signals provided by the external microenvironment during metastasis. Platelets closely interact with tumor cells during hematogenous metastasis and facilitate tumor development. However, the molecular mechanisms underlying this process are not fully understood.

Methods

RNA-sequencing was performed to screen differentially expressed genes mediated by platelets. The effects of platelet and CD39 on tumor metastasis were determined by experimental metastasis models with WT, NCG and CD39^-/- mice.

Results

RNA-sequencing results showed that platelets significantly up-regulated CD39 expression in tumor cells. CD39 is a novel immune checkpoint molecule and a key driver of immunosuppres

SUBMITTER: Ning Z 

PROVIDER: S-EPMC11058827 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature