Neoadjuvant chemotherapy is noninferior to chemoradiotherapy for early-onset locally advanced rectal cancer in the FOWARC trial.

ABSTRACT:

Background

The early-onset rectal cancer with rapidly increasing incidence is considered to have distinct clinicopathological and molecular profiles with high-risk features. This leads to challenges in developing specific treatment strategies for early-onset rectal cancer patients and questions of whether early-onset locally advanced rectal cancer (LARC) needs aggressive neoadjuvant treatment.

Methods

In this post hoc analysis of FOWARC trial, we investigated the role of preoperative radiation in early-onset LARC by comparing the clinicopathological profiles and short-term and long-term outcomes between the early-onset and late-onset LARCs.

Results

We revealed an inter-tumor heterogeneity of clinical profiles and treatment outcomes between the early-onset and late-ons

SUBMITTER: Cai J 

PROVIDER: S-EPMC11058860 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature