CPE correlates with poor prognosis in gastric cancer by promoting tumourigenesis.

ABSTRACT:

Aims

To investigate the potential functions and mechanisms of tumourigenesis in carboxypeptidase E (CPE) and its prognostic value in gastric cancer, and to develop a predictive model for prognosis based on CPE.

Results

Transcriptome level variation and the prognostic value of CPE in different types of cancers were investigated using bioinformatics analyses. The association between CPE and clinicopathological characteristics was specifically explored in gastric cancer. Elevated CPE expression was associated with poor survival and recurrence prognosis and was found in cases with a later clinical stage of gastric cancer. The CPE was considered an independent prognostic factor, as assessed using Cox regression analysis. The prognostic value of CPE was further verified through im

SUBMITTER: Lin J 

PROVIDER: S-EPMC11058891 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature