Aspirin vs Placebo as Adjuvant Therapy for Breast Cancer: The Alliance A011502 Randomized Trial.

ABSTRACT:

Importance

Observational studies of survivors of breast cancer and prospective trials of aspirin for cardiovascular disease suggest improved breast cancer survival among aspirin users, but prospective studies of aspirin to prevent breast cancer recurrence are lacking.

Objective

To determine whether aspirin decreases the risk of invasive cancer events among survivors of breast cancer.

Design, setting, and participants

A011502, a phase 3, randomized, placebo-controlled, double-blind trial conducted in the United States and Canada with 3020 participants who had high-risk nonmetastatic breast cancer, enrolled participants from 534 sites from January 6, 2017, through December 4, 2020, with follow-up to March 4, 2023.

Interventions

Participants were randomized (strat

SUBMITTER: Chen WY 

PROVIDER: S-EPMC11059055 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature