Determinants of Symptomatic Intracranial Progression After an Initial Stereotactic Radiosurgery Course.

ABSTRACT:

Purpose

Clinical and imaging surveillance of patients with brain metastases is important after stereotactic radiosurgery (SRS) because many will experience intracranial progression (ITCP) requiring multidisciplinary management. The prognostic significance of neurologic symptoms at the time of ITCP is poorly understood.

Methods and materials

This was a multi-institutional, retrospective cohort study from 2015 to 2020, including all patients with brain metastases completing an initial course of SRS. The primary outcome was overall survival (OS) by presence of neurologic symptoms at ITCP. OS, freedom from ITCP (FF-ITCP), and freedom from symptomatic ITCP (FF-SITCP) were assessed via Kaplan-Meier method. Cox proportional hazard models tested parameters impacting FF-ITCP and FF-S

SUBMITTER: Leng JX 

PROVIDER: S-EPMC11059392 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature