Health-related quality of life in children and adolescents with Marfan syndrome or related disorders: a controlled cross-sectional study.

ABSTRACT:

Background

This cross-sectional controlled study aims to assess health-related quality of life (HRQoL) of children and adolescents with a molecular diagnosis of Marfan syndrome (MFS) or related disorders and to evaluate the factors associated with HRQoL in this population. Sixty-three children with MFS and 124 age- and sex-matched healthy children were recruited. HRQoL was assessed using the Pediatric Quality of Life Inventory (PedsQL™) generic questionnaire. The correlation between HRQoL scores and the different continuous parameters (age, body mass index, disease severity, systemic score, aortic sinus diameter, and aerobic physical capacity) was evaluated using Pearson's or Spearman's coefficient. A multiple linear regression analysis was performed on the two health summary self-

SUBMITTER: Edouard T 

PROVIDER: S-EPMC11059743 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature