Effect of smoking cessation medications on intracranial aneurysm risk: A Mendelian randomization study.

ABSTRACT:

Introduction

We aim to assess the association between smoking behavior and intracranial aneurysms (IAs) and the effect of smoking cessation medications on IAs at the genetic level.

Methods

Causal effects of four phenotypes: 1) age at initiation of regular smoking, 2) cigarettes smoked per day, 3) smoking cessation, and 4) smoking initiation on IAs, were analyzed using two-sample inverse-variance weighted Mendelian randomization analyses. The effects of genes interacting with the smoking cessation medications were analyzed using cis-expression quantitative trait loci genetic instruments on IAs using summary statistics-based Mendelian randomization analyses. Colocalization analyses were then used to test whether the genes shared causal variants with IAs. The role of confoundin

SUBMITTER: Liang X 

PROVIDER: S-EPMC11059939 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature