Preventive effect of Lactobacillus johnsonii YH1136 against uric acid accumulation and renal damages.

ABSTRACT:

Background

Hyperuricemia (HUA) is a prevalent metabolic disorder whose development is associated with intestinal microbiota. Therefore, probiotics have emerged as a potential and safe approach for lowering uric acid (UA) levels. However, the underlying mechanisms of many effective probiotic strains remain unknown.

Methods and results

C57BL/6 mice were randomly divided into two groups: control and model groups. The model group received 12 weeks of potassium oxonate. Through 16s sequencing we found that HUA resulted in a significant decrease in the total diversity of all intestinal segments. When each intestinal segment was analyzed individually, the reduction in diversity was only significant in the cecum and colon sections. RDA analysis showed that lactobacilli in the rat co

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11059993 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature