Adaptation of the Mycobacterium tuberculosis transcriptome to biofilm growth.

ABSTRACT: Mycobacterium tuberculosis (M. tb), the causative agent of tuberculosis (TB), is a leading global cause of death from infectious disease. Biofilms are increasingly recognized as a relevant growth form during M. tb infection and may impede treatment by enabling bacterial drug and immune tolerance. M. tb has a complicated regulatory network that has been well-characterized for many relevant disease states, including dormancy and hypoxia. However, despite its importance, our knowledge of the genes and pathways involved in biofilm formation is limited. Here we characterize the biofilm transcriptomes of fully virulent clinical isolates and find that the regulatory systems underlying biofilm growth vary widely between strains and are also distinct from regulatory programs associated with other e

SUBMITTER: Youngblom MA 

PROVIDER: S-EPMC11060545 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature