Mesoscale simulations predict the role of synergistic cerebellar plasticity during classical eyeblink conditioning.

ABSTRACT: According to the motor learning theory by Albus and Ito, synaptic depression at the parallel fibre to Purkinje cells synapse (pf-PC) is the main substrate responsible for learning sensorimotor contingencies under climbing fibre control. However, recent experimental evidence challenges this relatively monopolistic view of cerebellar learning. Bidirectional plasticity appears crucial for learning, in which different microzones can undergo opposite changes of synaptic strength (e.g. downbound microzones-more likely depression, upbound microzones-more likely potentiation), and multiple forms of plasticity have been identified, distributed over different cerebellar circuit synapses. Here, we have simulated classical eyeblink conditioning (CEBC) using an advanced spiking cerebellar model embeddi

SUBMITTER: Geminiani A 

PROVIDER: S-EPMC11060558 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature