An algorithm for standardization of tumor Infiltrating lymphocyte evaluation in head and neck cancers.

ABSTRACT:

Purpose

The prognostic and predictive significance of pathologist-read tumor infiltrating lymphocytes (TILs) in head and neck cancers have been demonstrated through multiple studies over the years. TILs have not been broadly adopted clinically, perhaps due to substantial inter-observer variability. In this study, we developed a machine-based algorithm for TIL evaluation in head and neck cancers and validated its prognostic value in independent cohorts.

Experimental design

A network classifier called NN3-17 was trained to identify and calculate tumor cells, lymphocytes, fibroblasts and "other" cells on hematoxylin-eosin stained sections using the QuPath software. These measurements were used to construct three predefined TIL variables. A retrospective collection of 154 head a

SUBMITTER: Xirou V 

PROVIDER: S-EPMC11060915 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature