Increased Cortical Thickness in Alzheimer's Disease.

ABSTRACT:

Objective

Patients with Alzheimer's disease (AD) have diffuse brain atrophy, but some regions, such as the anterior cingulate cortex (ACC), are spared and may even show increase in size compared to controls. The extent, clinical significance, and mechanisms associated with increased cortical thickness in AD remain unknown. Recent work suggested neural facilitation of regions anticorrelated to atrophied regions in frontotemporal dementia. Here, we aim to determine whether increased thickness occurs in sporadic AD, whether it relates to clinical symptoms, and whether it occur in brain regions functionally connected to-but anticorrelated with-locations of atrophy.

Methods

Cross-sectional clinical, neuropsychological, and neuroimaging data from the Alzheimer's Disease Neuroimagi

SUBMITTER: Phan TX 

PROVIDER: S-EPMC11060923 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature